Lorcet is a combined drug, used for relieving moderate to severe pain symptoms, regardless of their causes. Lorcet without prescription is available on any online pharmacy.
Lorcet eliminates the pain symptoms of different origins due to the combination of two active ingredients: a Lorcet capsule or tablet contains 2.5 to 10 mg of Hydrocodone and 325-660 mg of Acetaminophen.
Hydrocodone is an analgesic or an anesthetic agent, which is an opioid receptor agonist. This group of receptors is very important in the formation of pain sensation. Lorcet contains a sufficient concentration of the analgesic, needed to suppress the activity of opioid receptors and thereby relieving pain symptoms.
Hydrocodone is an opioid analgesic, derivative of Codeine, but much better by its analgesic activity. In addition to relieving pain symptoms, another effect of the semi-synthetic opioid is cough elimination.
Another ingredient, contained in Lorcet – Acetaminophen, also known as Paracetamol or APAP (Acetyl-Para-Aminophenol), enhances the analgesic effect. The non-narcotic analgesic Acetaminophen acts only in the central nervous system and has no effect on the opioid receptors in the brain.
The combination of the opioid and non-narcotic analgesics in Lorcet provides a stronger analgesic activity, than each of the drugs individually. Paracetamol provides a fast relief of pain symptoms, and the opioid analgesic ensures a prolonged analgesic effect.
The maximum concentration of the active ingredients in the plasma is achieved in about 1.5-3 hours upon the intake of a Lorcet capsule. Since Paracetamol is metabolized in the liver, its half-life may be longer, if the patient has impaired liver function.
Lorcet dosage depends on the severity of pain and symptoms, the patient’s perceptibility to the drug and the dose of the active ingredients into one capsule. To relieve the pain symptoms, 1 to 6 Lorcet capsules should be taken per day.
Ordering Lorcet online without prescription may give you the following benefits:
- sustained relief from severe and chronic pain, especially caused by an injury or a surgery;
- double effect against pain – impact on pain centers in the brain and blockage of the pain transmission in the nerve endings;
- low chance of opioid addiction due to low doses of the narcotic analgesic.
Despite the fact that this anesthetic drug is a relatively affordable drug, available without prescription, Lorcet should be used very carefully. Due to the narcotic opiate contained, Lorcet may cause side effects and drug addiction. Hydrocodone is a semisynthetic narcotic drug, which, like all opioid analgesics, has a high potential for addiction.
However, Acetaminophen may not be absolutely safe for the body in case of Lorcet abuse. Too high doses of Acetaminophen may cause serious liver toxicity.
Both active components of Lorcet were used individually and later started to be combined. Acetaminophen was discovered in the 19th century, but until the middle of the 20th century this analgesic was not used in clinical practice. The first drug based on it was launched in the USA in 1953.
Carl Mannich and Helene Löwenheim, scientific researchers from Knoll Pharmaceuticals, the German pharmaceutical company, first synthesized Hydrocodone in the early 1920s. The opioid analgesic was based on a molecular formula of Codeine. Analgesics, containing semisynthetic opioid, have been used in many countries, including the USA.
The Controlled Substance Act (CSA) was adopted even before Lorcet release in the USA market. Under the new law, all drug components were divided into five health risks categories in descending order. Hydrocodone was in Schedule III as a substance with a risk of abuse.
Lorcet predecessor, based on narcotic and non-narcotic analgesics, was Vicodin. First it was launched for sale in 1978. The combination of an opioid analgesic and Acetaminophen in the Vicodin formulation was designed specifically to minimize potential risks from the opioid receptor agonist.
Later, other combined medications for pain treatment appeared in the USA pharmaceutical market, such as: Lortab, Norco and Zydone. July 8, 1982 Lorcet obtained the FDA approval.
If the patient has any doubts on buying Lorcet, he may find more information about the analgesic on such a well-known resource, like Wikipedia. In addition, many online pharmacies offer free consultations of medical professionals for those buying Lorcet without prescription.