Savella is a drug that is used to eliminate depression and anxiety disorders in patients with fibromyalgia. Patients, suffering from chronic musculoskeletal pain, may buy Savella without prescription.
Fibromyalgia is a disease, characterized by long-lasting pain symptoms throughout the entire body. Patients, exposed to fibromyalgia, are characterized by irritability, high levels of anxiety and sleep disorders.
Savella is intended for facilitating and eliminating the psychological aspects of fibromyalgia. This antidepressant relieves symptoms of stress and anxiety due to the active ingredient Milnacipran. It is a selective inhibitor of serotonin and norepinephrine reuptake, which are the main neurotransmitters, regulating mood and restoring emotional state after the depression.
High concentration of serotonin and norepinephrine persist in the neural connections of the brain, when you take Savella. Elevated levels of serotonin provide sedation, while as of norepinephrine – analgesia. Savella maintains norepinephrine concentration about three times longer than serotonin. This suggests that the analgesic effect of Savella is more pronounced than the antidepressant one.
By ordering Savella online without prescription, you may achieve the following positive effects in eliminating the norepinephrine symptoms:
- improvement of “sleep-wake” rhythm;
- increased pain threshold and reduced susceptibility to emotional pain;
- increased serotonin concentration, which results in the release of endorphins – chemical compounds that promote pain decrease.
Savella is well absorbed, reaching the maximum concentration in 2-4 hours after the ingestion, while as the elimination half-life is approximately 6-8 hours. Each subsequent dose increases the effect of this antidepressant on the serotonin and noradrenaline receptors. The maximum therapeutic effect of Savella is usually reached on the second day of treatment with this antidepressant.
Savella tablets purchased without prescription, may contain 12.5, 25, 50 and 100 mg of Milnacipran Hydrochloride, depending on the dose of the active ingredient.
The usual Savella dose is 100 mg per day, divided into two intakes. Yet, doctors prescribe 12.5 mg of Savella on the first day of treatment with this antidepressant. In the next two or three days, Savella is taken twice a day at a dose of 12.5 mg. Then, the daily dose of Savella may be increased to 50 mg, divided into two intakes.
Starting from the second week of therapy, patients should take 100 mg Savella, divided into two intakes. High doses of 200 mg should only be taken when lower doses prove ineffective.
Only a healthcare professional should select and adjust Savella dose. Some patients may get a relief in the first week of Savella use, depending on their individual characteristics. Others might require long-term use of this antidepressant for getting rid of the fibromyalgia symptoms. Qualitative improvement of fibromyalgia symptoms usually occurs within a month of Savella use.
- Savella should not be taken if:
- the patient is under 18 years of age;
- the woman is pregnant or breastfeeding at the time of the drug prescription;
- you are simultaneously using other antidepressants, like Moclobemide.
Savella discontinuation requires a gradual dosage reduction to avoid withdrawal symptoms. Sharp drug withdrawal may promote such adverse reactions, as irritability, headaches, tinnitus or convulsions.
The advantages of Savella:
- it contributes to an expressed reduction in depression and anxiety symptoms, as well as in pain symptoms of fibromyalgia already after the first week of its administration;
- improves the patient’s physical and mental condition;
- is safe to use, does not cause serious side effects, like other anti-depressants;
- restores sleep rhythms and improves the patient’s quality of life.
Savella may not be used as a drug for eliminating depressive disorders symptoms. This antidepressant should only be used in patients with a confirmed fibromyalgia diagnosis. The analgesic activity of Savella is independent from the influence of the drug on the patient’s emotional status.
Savella is one of the first Milnacipran-based drugs, which was used for the treatment of fibromyalgia. This antidepressant was initially developed in France in the second half of the 1990s, and used only for the relief of the depression symptoms. Yet, Milnacipran has become widely used in medical practice as a drug for the fibromyalgia treatment since 2000.
On January 15, 2009, Milnacipran under the brand name Savella became the first antidepressant, approved in the USA for the relief of fibromyalgia symptoms. Today, Savella pills are available for sale online without prescription in any online pharmacy.